A total 210 birds were reared upto the age of 4 weeks and the divided into 7 groups viz A, B, C, D, E, F and G, comprised of 30 birds in each group. At the age of 28 days the groups A to E were experimentally infected with Salmonella pullorum inoculation intraperitoneally with the dose rate of '/2 ml. The group F was infected but non-medicated and the group G was kept as control (non infected and non medicated). The groups A, B, C, D, E and E were treated with Anflox, Inoxyl, Triquine, Flumiquine and Gentamycine respectively. All the groups were kept under close observation to record clinical signs, mortality rate, weight gain and feed conversion ratio. Postmortem of dead birds was also conducted. The blood parameters TEC, TLC, and DLC were also estimated post medication on 1st, 3rd and 5th day. The mortality before medication in groups A, B, C, D, E and F was 10%, 16.67, 6.67%, 13.34%, 13.34% and 6.67% respectively. While the mortality during treatment in each group was 25.92%, 32%, 39.28%, 19.23%, 46.16%, 64.28% respectively. The mortality in control group was 6.66% during these days. According to this trial Flumiquine provided maximum protection against Salmonella pullorum infection and proved best in relation to weight gain and FCR. Anflox stood second in the list while Inoxyl was the 3rd drug which provided protection against the infection, whereas Triquine and Gentamycin were the least effective drugs. The signs which appeared after 18-24 hours post infection were listlessness, ruffled feathers, droopy wings, loss of appetite, poor growth, depression, increased thirst and severe diarrhoea of chalky white color. The post mortem findings were enlarged spleen, congested liver with streaked haemorrhages, congested and distended kidneys, grey hepatization in lungs and enlarged heart. The total erythrocytic count decreased in infected non-medicated birds while in medicated groups it remained in normal range. The same was true of total leucocytic count. However, in DLC the heterophil indicated increased percentage after inoculation of infection while the lymphocytes, basophils, eosinophils and monocytes remained within range after the infection. The findings of the present study elucidate the disease and help in diagnosis and treatment of this malady.